Rapidly detect and cost-effectively analyze somatic mutations as low as 1% in precious amounts of liquid biopsy or FFPE tissue samples

The ThunderBolts™ System is a fast, accurate and low-cost NGS target enrichment system that features award-winning instrumentation and pre-validated gene panels, as well as flexible open source options for scientists looking for custom solutions. The fast and simple workflow is optimized for Illumina NGS systems and compatible with liquid biopsy, FFPE and tissue samples with as low as 10 ng of starting DNA. Researchers gain rapid, accurate mutation profiles for a low overall cost per sample.

Advantages

• Single molecule droplet PCR: Generate 8 million PCR picodroplet reactions per well
• Pre-validated gene panels: Run the following panels that were developed in collaboration with a consortium of industry experts:
  • ThunderBolts™ Cancer Panel: Interrogate mutations/hotspots in 50 oncogenes, tumor suppressors and drug resistance markers
  • ThunderBolts™ Myeloid Panel: Target mutations/hotspots in 49 genes implicated in AML, MDS, MPN and myeloma diseases, including challenging genes such as CEBPA and NOTCH1.
• Minimal and flexible sample input requirements: Analyze a range of sample types (plasma, FFPE and tissue) with as low as 10 ng amplifiable DNA
• Streamlined workflow for Illumina NGS: Eliminate sequencing library preparation steps with RainDance DirectSeq™ workflow
• Highly sensitive: Detect minor allele frequencies as low as 1%
• Reduced time to result: Process 8 samples with <3 hours hands-on time, enabling sample-to-results in 2 days
• Custom content options: Create custom gene content panels using the ThunderBolts Open Source Consumables Pack
  
• Low cost per sample: Highly cost-effective sample-to-sequencing data economics

Streamlined Workflow

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The ThunderBolts™ System is for Research Use Only. Not for use in diagnostic procedures.