- Core Technology
- Targeted DNA Sequencing
- Gene Panels
- Service Partner Program
- Digital PCR
RainDance Technologies has collaborated with investigators at Emory University to design the industry’s most comprehensive genetic screening panel for human X-chromosome research. The XSeq™ Research Screening Panel enables scientists to interrogate 802 genes on the X chromosome simultaneously, and in a single assay, using next-generation sequencing (NGS) technology to detect specific known and novel mutations in a cost-effective manner.
Recent studies in human genetics indicate there are more than 800 protein-coding genes on the X chromosome, including many that play key roles in autism and other developmental disorders and intellectual disabilities.1,2 However, current cost and technology constraints make it difficult for researchers to detect many of the important sequence variants associated with these complex disorders. Whole-genome sequencing is expensive and not conducive for routine clinical use; hybridization-based sequence enrichment methods and whole-exome sequencing often lack the required genomic coverage and specificity to target and capture all of the genes and their 5’ promoter and 3’ untranslated regions (UTRs).
The RainDance XSeq panel provides the industry’s leading coverage of the X-chromosome genes associated with the full range of complex X-linked disorders.
The RainDance XSeq™ Research Screening Panel Advantage
The RainDance XSeq™ Research Screening Panel utilizes NGS technology to offer greater than 98% coverage from more than 800 genes encoded on the gene-rich human X chromosome. This includes more than 600 X-chromosome genes that have yet to be associated with a Mendelian disease, as well as all known Mendelian disorder genes. Coverage spans all exons and both the 5’ promoter region and 3’ UTR for each gene. A few of the more commonly sequenced genes represented in the XSeq panel include ALD, DMD, FMR1, F8 and GLA. With the XSeq panel, all of these can be sequenced together in a single powerful assay method.
*The RainDance XSeq™ Research Screening Panel is for research use only. Not for diagnostic purposes. Special order only.
1. Ross et al. (2005) The DNA sequence of the human X chromosome. Nature. Mar 17;434(7031):325-37.
2. Tarpey et al. (2009) A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet. May;41(5):535-43.
RainDance Technologies is pioneering digital biology and powering ground-breaking human health and life science research with its novel droplet-based technologies. The power, precision and simplicity of picodroplets enable researchers to answer complex questions with unprecedented sensitivity and quantitation.