Learn how researchers are implementing our picodroplet technology to profile and monitor genetic variation in myeloid disorders. The ThunderBolts™ Myeloid Panel is a next-generation sequencing (NGS) assay for studying important mutations in known genes implicated in the causation, prognosis and recurrence of myeloid disorders. The RainDrop Plus™ System is the industry’s most sensitive nucleic acid detection and monitoring platform, and the only unified instrument capable of performing both NGS Target Enrichment for mutation profiling and Digital PCR for subsequent mutation monitoring.
Superior Coverage and Uniformity
The ThunderBolts Myeloid Panel CEBPA amplicons are all covered ≥500X with a high degree of uniformity, whereas only 50% of the competitor's CEBPA amplicons are enriched ≥500X with very low coverage uniformity. Typical results inlcude:
- 99% coverage of amplicons at >500x (5000x avg reads/target)
- 97% uniformity at 500x (0.2x of mean)
CEBPA Depth of Coverage Associated with ThunderBolts Myeloid Panel (blue) and a Competitor Myeloid Panels (grey)
IGV Representation of CEBPA Amplicon Coverage Associated with ThunderBolts Myeloid Panel (blue) and a Competitor Myeloid Panel (grey)
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Droplet Based Genomic MRD Target Identification and Detection in AML with Dr. Brian Parkin, University of Michigan
An Independent Comparison: The Evaluation of Three Digital PCR Platforms for Residual Disease in Chronic Myeloid Leukemia with Mary Alikian, Ph.D., Hammersmith Hospital, Imperial College London
These posters were presented by RainDance customers at the Association for Molecular Pathology 2016 Annual Meeting.
Children's Hospital Colorado
Improving NGS Library Coverage Uniformity Using Single Molecule Droplet PCR for the Molecular Assessment of Acute Myeloid Leukemia
Johns Hopkins School of Medicine
Sensitive and Specific Detection of JAK2 V617F Using Digital Droplet PCR
In this video, Dr. Qi Wei, Director, Molecular Diagnostic Lab at Children's Hospital Colorado, shares his experiences with the only unified instrument for NGS Enrichment and Digital PCR.