Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples Laetitia Borsu, Julie Intrieri, Linta Thampi, Helena Yu, Gregory Riely, Khedoudja Nafa, Raghu Chandramohan, Marc Ladanyi, Maria E. Arcila
Digital PCR dynamic range is approaching that of real-time quantitative PCR Gerwyn M. Jonesa, Eloise Busbya, Jeremy A. Garsonb, Paul R. Grantc, Eleni Nastoulic, Alison S. Devonshirea, Alexandra S. Whale
Differential gene expression is tied to photo chemical efficiency reduction in virally infected Emiliania huxleyi Ilana C. Gilg, Stephen D. Archer, Sheri A. Floge, David M. Fields, Alex I. Vermont, Anna H. Leavitt, William H. Wilson, Joaquín Martínez Martínez*
Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations Eleonora Zonta, Fanny Garlan, Nicolas Pécuchet, Karla Perez-Toralla, Ouriel Caen, Coren Milbury, Audrey Didelot, Elizabeth Fabre, Hélène Blons, Pierre Laurent-Puig,
A Quantitative Analysis of Subclonal and Clonal Gene Mutations Pre- and Post-therapy in Chronic Lymphocytic Leukemia Nisar A. Amin, Erlene Seymour, Kamlai Saiya-Cork, Brian Parkin, Kerby Shedden and Sami N. Malek, From the Departments of Internal Medicine, Division of Hematology and O
An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer Everett J. Moding, Hooney D. Min, Katherine D. Castle, Moiez Ali, Loretta Woodlief, Nerissa Williams, Yan Ma, Yongbaek Kim, Chang-Lung Lee, and David G. Kirsch.
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M. Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L. Samuels, Rebecca Hoh, Jonah B. Sacha, Philip J. Norris, Toshiro Niki, Cecilia
Multiplex Preamplification of Serum DNA to Facilitate Reliable Detection of Extremely Rare Cancer Mutations in Circulating DNA by Digital PCR Jennifer B. Jackson,* Daniel S. Choi,* James D. Luketich,* Arjun Pennathur,* Anders Ståhlberg,* and Tony E. Godfrey*
Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers Elena Pereira1, Olga Camacho-Vanegas2, Sanya Anand2, Robert Sebra2, Sandra Catalina Camacho2, Leopold Garnar-Wortzel2, Navya Nair1, Erin Moshier4, Melissa Wooten2,
RainDance Technologies® is making complex genetics simple. The company’s ultra-sensitive genomic tools enable research of novel non-invasive liquid biopsy applications that should result in more accurate, reliable, cost-effective, and early detection of cancer and other inherited and infectious diseases. Major research institutions and laboratories around the world rely on the performance of RainDance systems. Based outside Boston, Massachusetts, the company supports customers using RainDrop® Digital PCR, as well as the ThunderStorm® and ThunderBolts™ Next-Generation Sequencing Enrichment Systems through its international sales and service operations, as well as a global network of distributors and commercial service providers. Both technology platforms have been recognized by The Scientist as Top 10 Innovations with the RainDrop System winning the award in 2014 and the ThunderStorm System winning the award in 2011.